Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

Figure 9

Effect of glucocorticoid (GR) and mineralocorticoid (MR) receptor blockades on renal adenosine deaminase-xanthine oxidase pathway of uric acid production in Wistar dams exposed to combined oral contraceptives (COC). GR and MR blockades increased renal adenosine (a), both GR and MR blockades reduced renal ADA (adenosine deaminase) (b), XO (xanthine oxidase) (c) and UA (uric acid) (d) in COC-treated Wistar rat dams. Post gestational COC exposure, GR and MR blockades were carried out for eight weeks after the 3-week postgestational period. Data were presented as , and was taken as statistically significant. vs. DAM; ^# vs. DAM+COC. Data were analyzed by one-way ANOVA and Bonferroni’s post hoc analysis. DAM: control; DAM+COC: combined oral contraceptive exposure; DAM+COC+GR: COC exposure with glucocorticoid receptor blockade; DAM+COC+MR: COC exposure with mineralocorticoid receptor blockade.

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