Research Article

Assessment of Alamandine in Pulmonary Fibrosis and Respiratory Mechanics in Rodents

Table 1

Hemodynamic data and spectral and symbolic analysis results. CO: control rats; ALA: rats treated only with alamandine; BLM: rats treated with bleomycin; BLM+ALA: rats treated with bleomycin+alamandine. HR: heart rate; bpm: beats per minute; ABP: average blood pressure. HRV: heart rate variability; LF: low- and HF: high-frequency component; a: absolute and nu: normalized units. A one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison posttest was used for ABP and HR evaluation. The Kruskal-Wallis and the post hoc Dunn’s multiple comparison tests were performed to detect differences in spectral and symbolic analysis. Data represent , and a was considered statistically significant.

Spectral analysis
CO ()ALA ()BLM ()BLM+ALA ()

ABP (mmHg)0.81
HR (bpm)0.14
HRV (ms2)0.90
LFa (ms2)0.68
HFa (ms2)0.96
LFnu0.96
HFnu0.96
LF/HF ratio0.97
Symbolic analysis (%)
0V pattern0.99
1V pattern0.40
2LV pattern0.34
2UV pattern0.94