Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer

Table 1

Changes in gene expression for components of the RAS and related proteins in CRC tissue samples.

Gene	Protein	Non-tumor tissue ()	Tumor tissue ()	Significance level (uncorrected for multiple comparisons)	Significance level (corrected for multiple comparisons)
AGT	Angiotensinogen
REN	Renin
ACE	Angiotensin-converting enzyme				NS
AGTR1	AT1 Ang II receptor subtype				NS
AGTR2	AT2 Ang II receptor subtype				NS
ATP6AP2	Prorenin receptor				p =0.05
CMA1	Chymase				NS
LNPEP	Ang IV receptor, insulin-regulated aminopeptidase				NS
ENPEP	Aminopeptidase A
ANPEP	Aminopeptidase N
ACE2	Angiotensin-converting enzyme-2				NS
MME	Neprilysin		7.510.31
PRCP	Prolyl carboxypeptidase				NS
PREP	Prolyl endopeptidase
MAS1	Mas, Ang 1-7 receptor
NLN	Neurolysin
THOP	Thimet oligopeptidase	8.2 ± 0.11	7.28 ± 0.12

Paired -test; Sidak’s correction: or or ; NS is nonsignificant.