Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer

Table 2

Change of the RAS gene expression in various cancers.

Cancer type	RAS gene	RAS protein	Change	Citation
Invasive duct cell breast cancer	MMP	Neprilysin	Downregulated	Stephen et al. [113]
CRC liver metastases	AGTR1	AT1R	Upregulated	Neo et al. [15], Zhou et al. [27]
	AGTR2	AT2R	Upregulated	Neo et al. [15]
	AGT	Angiotensinogen	No change	Neo et al. [15]
	ACE	Angiotensin-converting enzyme	Upregulated	Neo et al. [15]
	MAS1	Mas receptor	Upregulated	Neo et al. [15]
CRC	AGTR1	AT1R	Upregulated, protumoral, and dose dependent on Ang II concentration	Zhou et al. [27]
	AGTR2	AT2R	Biphasic, Ang II dose dependent (, )	Zhou et al. [27]
	AGTR2	AT2R	Protumor at low (Ang II), antitumoral effects at high (Ang II)	Zhou et al. [27]
Breast cancer	AGTR2	AT2R	Upregulated	Zhou et al. [27]
Pancreatic cancer	AGTR2 via ATII	AT2R via ATII	Upregulated	Zhou et al. [27]
Chemically induced lung cancer	AGTR2	AT2R	Upregulated	Zhou et al. [27]
CRC, lymph node metastases	ACE	Angiotensin-converting enzyme	Allele dependent	Zheng et al. [16]