Research Article
Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer
Table 3
Use of RAS inhibitors and other medications in various cancers.
| Medication | Cancer type | Effect of medication on cancer type | Citation |
| inhibitors | CRC | Downregulated tumor growth | Makar et al. [17] | years | CRC | Decreased RISK of CRC | Makar et al. [17] | CCB years | CRC | No change | Makar et al. [17] | Statins, ACEI, CCBs, diuretics | CRC | No change in risk of CRC | Boudreau et al. [100] | ACEI (dose related) | Adenomatous polyps | Decreased risk of CRC via downregulation of adenomatous polyps | Kedika et al. [18] | ACEI and ARB combination | Cancer (nonspecific) | Increased risk of cancer | Bangalore et al. [101] | ACEI | Breast, prostate, renal, and small cell cancer | Improved survival outcomes | Coulson et al. [86] | Losartan (ARB) | Breast Cancer | Delays occurrence and progression of invasive breast cancer | Coulson et al. [86] | Captopril (ACEI) | CRC liver metastases | Decreased tumor metastases | Neo et al. [15] |
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