Eplerenone Prevents Cardiac Fibrosis by Inhibiting Angiogenesis in Unilateral Urinary Obstruction Rats

Figure 8

Aldosterone stimulates angiogenesis, and End-MT is activated by the MR/IL-1β/VEGFA signaling pathway. (a) The protein expression of NF-κB, IL-1β, VEGFA, and VEGFR2 in cardiac tissue of UUO rats was detected by western blot. Each value represents the . . vs. sham. ^# vs. UUO. (b) The SGK-1, NF-κB, and IL-1β mRNA levels were detected via real-time PCR. Each value represents the . . vs. Sham. ^# vs. UUO.

(a)

(b)