Sex Difference in MasR Expression and Functions in the Renal System

Table 1

MasR alteration in different physiological and pathological conditions.

Condition/model	Renal MasR expression	Ref	Human/animal
Normotensive	Female > male	[48, 49]	Male and female Sprague-Dawley rats
Normotensive+angiotensin 1-7 infusion	No change	[51]	Male Wistar rats
SHR+angiotensin 1-7 infusion	Decrease	[51]	Male Wistar rats
2K1C	Decrease	[52]	Male Sprague-Dawley rats
SHR+AngII administration	Female > male	[54]	Wistar rats
I/R	Increase	[59, 60]	Male Wistar rats and male C57BL/6 wild-type mice
Diabetic nephropathy	Decrease	[61]	Male C57BL/6 JAX mice
Diabetic nephropathy+AT1R blockade	Increase	[65]	Human

SHR: spontaneously hypertensive rats; 2K1C: two-kidney, one clip hypertensive rats; I/R: renal ischemia/reperfusion.