Sex Difference in MasR Expression and Functions in the Renal System

Table 2

The effect of angiotensin 1-7 receptor (MasR) antagonist (A779) in the renal system in different experimental models.

Antagonist MasR (A779)
Model	Effect
	Male	Female	Ref
Water loaded male Wistar rats	⬆Urine volume	—	[70]
Virgin female	—	⬆Urine volume	[72]
Pregnant female	—	⬇Urine volume	[72]
Male and female SHRs+Ang II infusion	⬆Blood pressure (there was no sex difference)	⬆Blood pressure (there was no sex difference)	[54]
Male and female Wistar rats+Ang 1-7 infusion	⬇RBF response to Ang 1-7 (the decrease was not significant)	⬇RBF response to Ang 1-7	[88]
Male Wistar rats	⬇RBF	—	[89]
OVX female Wistar rats+ERT	—	⬆RBF response to Ang 1-7 infusion (this response increased significantly in nonestradiol treated compared to the estradiol-treated rats)	[90]
Male and female Wistar rats+block of AT1R+AT2R	⬆RBF response to Ang 1-7 infusion	This response did not occur in female animals	[91, 92]
Male and female Wistar rats+block of AT1R+AT2R	RBF response did not any change between males and females	RBF response did not any change between males and females	[93]
OVX female Wistar rats+BK agonist	—	⬆RBF response to Ang 1-7 infusion (in OVX group was greater than OVX+ERT group insignificantly)	[95]
OVX female Wistar rats+B2R antagonist+ERT	—	⬆RBF response to Ang 1-7 infusion (when B2R alone blocking, the role of estradiol was highlighted)	[96]
Male and female Wistar rats+PD123319	⬇RBF response to Ang II infusion	Attenuated ⬇ RBF response to Ang II infusion in females but not male	[97]
Male and female Wistar rats+2K1C	⬆RBF responses to Ang II infusion (no difference between the sexes)	⬆RBF responses to Ang II infusion (no difference between the sexes)	[98]
Male and female Wistar rats+2K1C+AT1R block	⬇RBF responses to Ang II infusion (this response in males significantly more than in females)	⬇RBF responses to Ang II infusion	[98]
OVX female Wistar rats+ERT	—	⬇RBF response to Ang II infusion (the reduction was significant compared to other groups)	[99]
Female Wistar rats+2K1C+ERT	—	⬇RBF response to Ang II infusion (there was no difference between groups)	[99]
Male Wistar rats+2K1C+IPC+I/R	⬆RBF response to Ang II infusion (significant difference with sham group)	—	[100]
Male Wistar rats+2K1C+I/R	⬆RBF response to Ang II infusion (significant difference with sham group)	—	[100]
Male and female Wistar rats+moderate I/R	⬆RBF response to Ang II infusion (was not significant compared to the vehicle group)	⬆RBF response to Ang II infusion (was significant compared to the vehicle group)	[101]
Male and female Wistar rats+moderate I/R+PD123319	⬆RBF response to Ang II infusion (was not significant compared to the vehicle group)	⬆RBF response to Ang II infusion (was significant compared to the vehicle group)	[101]
Male Wistar rats	⬇RBF response to Ang 1-7 infusion	—	[104]
Male Wistar rats+UUO	⬇RBF response to Ang 1-7 infusion	—	[104]
Male Wistar rats+RUUO	⬇RBF response to Ang 1-7 infusion	—	[104]
Male Wistar rats+normal-sodium diet	Increase GFR, had no significant effect on MAP, UF, UNaV, or FENa	—	[105]
Male Wistar rats+low-sodium diet	No effect on GFR, had no significant effect on MAP, UF, UNaV, or FENa	—	[105]

I/R: ischemia/reperfusion; OVX: ovariectomy; ERT: estrogen replacement therapy; AT1R: angiotensin II type 1 receptor; AT2R: angiotensin II type 2 receptor; BK: bradykinine; B2R: bradykinin B2 receptor; IPC: ischemia preconditioning; RBF: renal blood flow; RVR: renal vascular resistance; Ang II: angiotensin II; Ang 1-7: angiotensin 1-7; UUO: unilateral ureteral obstruction; RUUO: UUO removal; 2K1C: two-kidney, one clip hypertensive model; SHR: spontaneously hypertensive rats.