Tolvaptan Improves Contrast-Induced Acute Kidney Injury

Figure 2

Effect of tolvaptan on contrast-induced acute kidney injury. Rats were divided into following four groups: The control group (control, ), contrast-induced nephropathy group (CIN, ), CIN rats administered tolvaptan group (CIN + TOL, ), and CIN rats administered tolvaptan and Nrf2 inhibitor ML385 group (CIN + TOL + ML385, ). Serum was collected from each group of rats. (a)–(c) Biochemical detection of levels of BUN (a), Cr (b), and NGAL (c). (d, e) ELISA detection of Cys-C (d) in rat serum and KIM-1 (e) levels in rat urine. (f) Representative H&E staining of kidney sections and histopathological scoring of renal injury. BUN: blood urea nitrogen; Cr: creatinine; NGAL: neutrophil gelatinase-associated lipocalin. Data are presented as . , , and vs. control group; ^# and ^## vs. CIN group; & and && vs. CIN + TOL group.

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