Tolvaptan Improves Contrast-Induced Acute Kidney Injury

Figure 4

Effects of tolvaptan on contrast-induced acute kidney injury caused oxidative stress and mitochondrial function. Kidney tissues were collected from each group of rats.(a)–(c) The level of myeloperoxidase (MPO, (a)), superoxide dismutase (SOD, (b)), and glutathione peroxidase (GSH-Px, (c)) was measured. (d) The protein expression of DRP1, MFN2, and PINK1 in rat kidney tissues was detected by western blot. CIN: contrast-induced nephropathy; TOL: tolvaptan; ML385: Nrf2 inhibitor. per group. Data are presented as . , , and vs. control group; ^#, ^##, and ^### vs. CIN group; &, &&, and &&& vs. CIN + TOL group.

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