Exploring the Impact of ACE Inhibition in Immunity and Disease

Figure 4

A summary of immune cellular and cytokine changes with ACE inhibitor administration. Importantly, ACEi treatment results in a significant reduction in proinflammatory cytokine production, but these changes appear to be dose-, host-, and disease-dependent. Captopril and lisinopril have been extensively studied in both mice and human autoimmune models but the mechanisms of action are not well understood.