Fibrinogen-to-Albumin Ratio Predicts Postcontrast Acute Kidney Injury in Patients with Non-ST Elevation Acute Coronary Syndrome after Implantation of Drug-Eluting Stents

Table 1

Baseline characteristics of patients with and without PC-AKI.

Variable	Total patients	Non-PC-AKI	PC-AKI	value
	872	758	114
Male (, %)	554 (63.5)	493 (65.0)	61 (53.5)	0.017
Age (years)				0.904
BMI (kg/m^2)				0.143
Previous stroke (, %)	186 (21.3)	159 (21.0)	27 (23.7)	0.510
Hypertension (, %)	627 (71.9)	539 (71.1)	88 (77.2)	0.178
Diabetes (, %)	265 (30.4)	222 (29.3)	43 (37.7)	0.068
Smoking (, %)	244 (28.0)	216 (28.5)	28 (24.6)	0.383
Anemia (, %)	128 (14.7)	98 (11.9)	30 (26.3)	<0.001
CKD (, %)	20 (2.3)	16 (2.1)	4 (3.5)	0.318
NSTEMI (, %)	155 (17.8)	128 (16.9)	27 (23.7)	0.077
CHF (, %)	84 (9.6)	59 (7.8)	25 (21.9)	<0.001
SBP (mmHg)				0.141
DBP (mmHg)				0.883
Leukocyte (10^9/L)	6.5 (5.5, 7.8)	6.4 (5.5, 7.7)	6.8 (5.6, 8.2)	0.090
Hemoglobin (g/L)				0.001
Platelet (10^9/L)	198 (165, 237)	196 (165, 235)	212 (168, 249)	0.060
Fasting blood glucose (mmol/L)	5.8 (5.2, 7.3)	5.9 (5.3, 7.4)	6.0 (5.2, 8.2)	0.023
SCr (μmol/L)	75 (65, 88)	75 (64, 87)	79 (67, 95)	0.056
eGFR (mL/min/1.73 m^2)	87.0 (72.2, 99.1)	87.7 (73.6, 99.3)	79.9 (62.7, 97.6)	0.007
Uric acid (μmol/L)	350 (293, 412)	350 (294, 409)	349 (284, 420)	0.851
Triglyceride (mmol/L)	1.4 (1.0, 2.1)	1.4 (1.0, 2.1)	1.6 (1.0, 2.2)	0.162
TC (mmol/L)	4.4 (3.7, 5.2)	4.4 (3.7, 5.2)	4.5 (3.8, 5.5)	0.121
HDL-C (mmol/L)	1.1 (1.0, 1.3)	1.1 (1.0, 1.3)	1.1 (0.9, 1.3)	0.227
LDL-C (mmol/L)	2.7 (2.1, 3.3)	2.6 (2.1, 3.3)	2.8 (2.1, 3.5)	0.197
PT ()				0.551
APTT ()				0.714
D-dimer (μg/L)	92 (52, 151)	89 (50, 143)	122 (64, 181)	<0.001
Fibrinogen (g/L)				<0.001
Albumin (g/L)				<0.001
FAR (%)				<0.001
Mehran score	4 (1, 5)	3 (1, 5)	5 (3, 7)	<0.001
HbA1c (%)	6.0 (5.6, 6.8)	6.0 (5.6, 6.8)	6.2 (5.7, 7.2)	0.027
LVEF (%)	67 (62, 72)	67 (62, 72)	68 (60, 72)	0.585
Procedural characteristics
Left main disease (, %)	61 (7.0)	55 (7.3)	6 (5.3)	0.437
Three-vessel disease (, %)	337 (38.7)	287 (37.9)	50 (43.9)	0.220
Number of stents				0.916
Contrast volume (mL)	100 (100, 100)	100 (100, 100)	100 (100, 200)	0.181
Hydration (, %)	714 (81.9)	639 (84.3)	75 (65.8)	<0.001
Medication use (, %)
Aspirin	857 (98.3)	744 (98.2)	113 (99.1)	0.707
Clopidogrel/ticagrelor	870 (99.8)	757 (99.9)	113 (99.1)	0.245
ACEI/ARB	485 (55.6)	421 (55.5)	64 (56.1)	0.904
-Blockers	683 (78.3)	592 (78.1)	91 (79.8)	0.677
Statin	869 (99.7)	756 (99.7)	113 (99.1)	0.344
Diuretics	96 (11.0)	69 (9.1)	27 (23.7)	<0.001

PC-AKI: postcontrast acute kidney injury; BMI: body mass index; CKD: chronic kidney disease; NSTEMI: non-ST elevation myocardial infarction; CHF: congestive heart failure; SBP: systolic blood pressure; DBP: diastolic blood pressure; SCr: serum creatinine; eGFR: estimated glomerular filtration rate; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; PT: prothrombin time; APTT: activated partial thromboplastin time; FAR: fibrinogen-to-albumin ratio; HbA1c: hemoglobin A1c; LVEF: left ventricular ejection fraction; ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker.