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Journal of Sensors
Volume 2012, Article ID 640780, 5 pages
Research Article

Theoretical Study on the Detection of Tilted Lipid Bilayers Using Surface Plasmon Resonance Techniques

Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan

Received 12 October 2011; Revised 18 January 2012; Accepted 18 January 2012

Academic Editor: Chao-Min Cheng

Copyright © 2012 Koyo Watanabe and Koji Matsuura. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Effective refractive indices detected using surface plasmon resonance techniques are calculated as a function of the tilt angle of lipid bilayers in a multilayered model. The changes in the effective refractive indices are derived from the shift of an excitation angle of surface plasmon. To obtain effective refractive index plots, we determined refractive index changes in the lipid bilayers with 3 and 5 nm thicknesses as a function of tilt angle and obtained a relationship between the effective refractive index and tilt angle. We also showed that the effective refractive index depended on the lipid bilayers thickness and anisotropic permittivities, which vary with interchain distance.