Remote healthcare services are made possible with telehealth monitoring systems, also known as telemedicine, telemonitoring, e-health, etc. Military and space technology departments have already been using this technology for some time. It uses a wide range of sensors to measure strength, muscle activities, blood pressure, etc. Many technologies like bio-sensing, information processing, and communication systems with AI are incorporated for better accuracy, increasing the scope for wider application areas. However, the need for a strong network infrastructure, battery standby capacity, data security, patient privacy, and rights are some disadvantages of telehealth monitoring systems.

Biosensors and nanosensors are increasingly being utilized as clinical diagnostic tools to monitor a patient’s day-to-day activities. Cardiovascular diseases can be easily monitored with smart implants such as coronary stents and endoSure sensors. Though powering the implants is still a major constraint, many orthopedic implants help patients with mobility complications, replacement of joints and bones, and the functional restoration of damaged structures. Early detection of infectious diseases including can be made possible by integrating smart materials and biosensors. Dental implant technology not only helps patients in the restoration of function but also in appearance enhancement. Invasive devices are a major reason why some patients resist telehealth monitoring systems. With non-invasive devices, vital signals for chronic diseases such as cancer, cognitive impairment, orthopedic surgery, cardiovascular disease, and sleep disorders can be successfully measured. Such non-invasive smart implants provide real-time health data collection, early detection, effective disease prevention, and more precise treatment for patients. Telehealth monitoring systems generate a continuous stream of data, so limited memory space, range of communication, data transfer rates, size of implants, implant failure, and its calibrations are some of the major limiting factors for telehealth monitoring systems.

The aim of this Special Issue is to provide a forum for different research efforts towards the development, applications, and challenges of deploying advanced sensors and sensing technologies for telehealth monitoring systems. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Ubiquitous and unobtrusive monitoring digital health systems for physiological issues
• Deployment of non-invasive smart implant sensors for telehealth monitoring systems
• Health hazards imposed by invasive and non-invasive smart implants in remote patient monitoring systems
• Catastrophic repercussions due to personal health information exposure and privacy risks
• IoT sensor devices in the healthcare monitoring systems
• Healthcare tracking device with location recognition precision sensors
• Smart bands as body sensors for detecting and controlling emotions
• Non-invasive biosensing devices for rapid and accurate prostate cancer diagnosis
• Using biomarkers with multiplex biosensor platforms to achieve accurate diagnostic tests
• Glucose sensors development in controlling the rise and progression of diabetes-related complications
• Metal nanoparticles-based disposable enzymatic and non-enzymatic biosensor applications in telehealth monitoring systems
• Nanocomposite biosensor design for ultrasensitive diagnosis and extended monitoring of disease biomarkers
• Miniaturized wearable electrochemical sensors in the clinical management of Parkinson’s disease
• Optical biosensors based on different 2D materials for biological imaging and biomedicine
• Nanointerface sensitized microfiber sensor for early detection of cancer