Treatment of Locally Advanced Melanoma by Isolated Limb Infusion with Cytotoxic Drugs

Table 2

Isolated limb infusion studies using melphalan and actinomyocin-D [17–23].

Author, year	No. of patients	Response criteria	CR	PR	SD	PD
Mian et al., 2001 [19]	9*	Best response	44%	56%	0%	0%
Lindnér et al., 2002 [21]	128	Best response	41%	43%	12%	4%
Brady et al., 2006 [23]	22**	3 months	23%	27%	0%	50%
Kroon et al., 2008 [17]	185	Best response	38%	46%	10%	6%
Beasley et al., 2008 [20]	50	3 months	30%	14%	10%	46%
Marsden, 2008 [24]	16***	Unknown	26%	58%	—	16%
Barbour et al., 2009 [22]	74	Best response	24%	30%	37%	7%
Beasley et al., 2009 [18]	128	3 months	31%	33%	7%	29%

CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease.
*3 patients had >1 ILIs.
**1 patient had advanced sarcoma.
***3 patients had >1 ILIs, 4 patients had squamous cell carcinoma, and 2 patients had Merkel cell carcinoma.