Histopathological Variants of Cutaneous Squamous Cell Carcinoma: A Review

Table 1

Histological differences between low-grade and high-grade SCC.

	Low-Grade SCC
	Well to moderately differentiated: intercellular bridges and keratin pearls
	Tumor cells arranged in solid or sheet-like patterns
	Association with solar damage and precursor actinic keratosis
	Diameter less than 2 cm
	Depth less than 2 mm
	High-Grade SCC
	Poorly differentiated: clear-cell, sarcomatoid, or single cell features
	Presence of infiltrating individual tumor cells
	Arising de novo or in site of prior injury (ulcer, burn scar, or osteomyleitis)
	Perineural and/or perivascular invasion
	Diameter greater than 2 cm
	Depth greater than 2 mm