Clinical Study
Basal Cell Carcinomas in Gorlin Syndrome: A Review of 202 Patients
Table 1
Diagnostic criteria for Gorlin Syndrome. A diagnosis can be made when 2 major or 1 major and 2 minor criteria are fulfilled.
| Major criteria | Minor criteria |
| Lamellar (sheet-like) calcification of the falx or clear evidence of calcification in an individual younger than age of 20 years | Childhood medulloblastoma | Jaw keratocyst | Lympho-mesenteric or pleural cysts | 2 or more palmar/plantar pits | Macrocephaly (OFC >97th centile) | Multiple BCCs (more than five in a lifetime) or a BCC before age of 30 years. | Cleft lip/palate | First degree relative with Gorlin Syndrome | Vertebral/rib anomalies such as bifid/splayed/extra ribs or bifid vertebrae | Preaxial or postaxial polydactyly | Ovarian/cardiac fibromas | Ocular anomalies (cataract, developmental defects, and pigmentary changes of the retinal epithelium) |
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