Pigmentation, Melanocyte Colonization, and p53 Status in Basal Cell Carcinoma
Figure 2
Melanocytic colonization in a BCC expressing mutant p53. Depicted are immunohistochemically stained tissue sections of a BCC displaying approximately 10% melan-A positive melanocytes (a) and high levels of nuclear p53 in 90% of the tumor cells (c). The specimen shows strong pigmentation in the centre of the lesion (b), and sequencing revealed the presence of a c380t mutation leading to an S127F amino acid exchange (d).
