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Journal of Skin Cancer
Volume 2011, Article ID 541405, 16 pages
http://dx.doi.org/10.1155/2011/541405
Review Article

Deciphering Squamous Cell Carcinoma Using Multidimensional Genomic Approaches

1Department of Integrative Oncology, British Columbia Cancer Agency Research Centre, Vancouver BC, Canada V5Z 1L3
2Department of Pediatrics, Center for Molecular and Human Genetics, The Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA

Received 2 August 2010; Accepted 26 October 2010

Academic Editor: S. Ugurel

Copyright © 2011 Ewan A. Gibb et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Squamous cell carcinomas (SqCCs) arise in a wide range of tissues including skin, lung, and oral mucosa. Although all SqCCs are epithelial in origin and share common nomenclature, these cancers differ greatly with respect to incidence, prognosis, and treatment. Current knowledge of genetic similarities and differences between SqCCs is insufficient to describe the biology of these cancers, which arise from diverse tissue origins. In this paper we provide a general overview of whole genome approaches for gene and pathway discovery and highlight the advancement of integrative genomics as a state-of-the-art technology in the study of SqCC genetics.