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Journal of Skin Cancer
Volume 2011, Article ID 790509, 5 pages
http://dx.doi.org/10.1155/2011/790509
Case Report

No-Needle Jet Intradermal Aminolevulinic Acid Photodynamic Therapy for Recurrent Nodular Basal Cell Carcinoma of the Nose: A Case Report

1RoseLab Skin Optics Laboratory, 3333 Graham Boulevard, Suite 206, Montreal, Quebec, Canada H3R 3L5
2Dermatology Division, Department of Medicine, McGill University, ontreal, Quebec, Canada H3G 1Y6

Received 27 July 2010; Revised 17 September 2010; Accepted 23 September 2010

Academic Editor: Robert Dellavalle

Copyright © 2011 Daniel Barolet and Annie Boucher. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Photodynamic therapy (PDT) with aminolevulinic acid (ALA) to treat nodular basal cell carcinoma (BCC) has been shown to be beneficial. The success rate of ALA-PDT in the treatment of nodular BCC is dependent on optimal penetration of the photosensitizing agent and subsequent PpIX production. To enhance topical delivery of drugs intradermally, a needleless jet injection (NLJI), which employs a high-speed jet to puncture the skin without the side effects of needles, was used in one patient with recurrent BCC of the nose. Photoactivation was then performed using red light emitting diode [CW 630 nm, irradiance 50 mW/cm2, total fluence 51 J/cm2] for 17 minutes. Excellent cosmesis was obtained. Aside from mild crusting present for six days, no other adverse signs were noted. Clinically, there was no recurrent lesion up two years postintervention. Additional studies in larger samples of subjects are needed to further evaluate this promising technique.