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Journal of Skin Cancer
Volume 2011, Article ID 845863, 6 pages
http://dx.doi.org/10.1155/2011/845863
Review Article

Management of Melanoma Brain Metastases in the Era of Targeted Therapy

1Section of Melanoma, Renal Cancer and Immunotherapy, Nevada Cancer Institute, One Breakthrough Way, Las Vegas, NV 89135, USA
2Comprehensive Cancer Centers of Nevada, Henderson, NV 89014, USA
3US Oncology Research Developmental Therapeutics and Genitourinary Committees, Woodloch, TX, USA
4University of Nevada, Reno, NV, USA

Received 16 February 2011; Accepted 7 November 2011

Academic Editor: John M. Kirkwood

Copyright © 2011 Daniela Gonsalves Shapiro and Wolfram E. Samlowski. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, R. Siegel, J. Xu, and E. Ward, “Cancer statistics, 2010,” CA Cancer Journal for Clinicians, vol. 60, no. 5, pp. 277–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Y. Wen, P. M. Black, and J. S. Loeffler, “Metastatic brain cancer,” in Cancer: Principles and Practice of Oncology, V. T. DeVita, S. Hellman, and S. A. Rosenberg, Eds., pp. 2655–2670, Lippincott, Williams & Wilkins, Philadelphia, Pa, USA, 6th edition, 2001. View at Google Scholar
  3. E. L. Korn, P. Y. Liu, S. J. Lee et al., “Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials,” Journal of Clinical Oncology, vol. 26, no. 4, pp. 527–534, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. K. T. Flaherty, I. Puzanov, K. B. Kim et al., “Inhibition of mutated, activated BRAF in metastatic melanoma,” New England Journal of Medicine, vol. 363, no. 9, pp. 809–819, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. F. S. Hodi, S. J. O'Day, D. F. McDermott et al., “Improved survival with ipilimumab in patients with metastatic melanoma,” New England Journal of Medicine, vol. 363, no. 8, pp. 711–723, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. W. E. Samlowski, G. A. Watson, M. Wang et al., “Multimodality treatment of melanoma brain metastases incorporating stereotactic radiosurgery (SRS),” Cancer, vol. 109, no. 9, pp. 1855–1862, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. M. H. Amer, M. Al-Sarraf, L. H. Baker, and V. K. Vaitkevicius, “Malignant melanoma and central nervous system metastases. Incidence, diagnosis, treatment and survival,” Cancer, vol. 42, no. 2, pp. 660–668, 1978. View at Google Scholar · View at Scopus
  8. J. K. Patel, M. S. Didolkar, J. W. Pickren, and R. H. Moore, “Metastatic pattern of malignant melanoma. A study of 216 autopsy cases,” American Journal of Surgery, vol. 135, no. 6, pp. 807–810, 1978. View at Google Scholar · View at Scopus
  9. D. E. Bullard and H. F. Seigler, “Central nervous system metastases in malignant melanoma,” Neurosurgery, vol. 8, no. 1, pp. 26–30, 1981. View at Google Scholar · View at Scopus
  10. D. R. Budman, E. Camacho, and R. E. Wittes, “The current causes of death in patients with malignant melanoma,” European Journal of Cancer and Clinical Oncology, vol. 14, no. 4, pp. 327–330, 1978. View at Google Scholar · View at Scopus
  11. P. D. Schellinger, H. M. Meinck, and A. Thron, “Diagnostic accuracy of MRI compared to CCT in patients with brain metastases,” Journal of Neuro-Oncology, vol. 44, no. 3, pp. 275–281, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Maher and A. C. McKee, “Neoplasms of the central nervous system,” in Atlas of Diagnostic Oncology, A. T. Skarin and G. P. Canellos, Eds., pp. 60–116, Elsevier Science, London, UK, 3rd edition, 2003. View at Google Scholar
  13. M. S. van Breemen, E. B. Wilms, and C. J. Vecht, “Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management,” Lancet Neurology, vol. 6, no. 5, pp. 421–430, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. C. J. Vecht, G. L. Wagner, and E. B. Wilms, “Interactions between antiepileptic and chemotherapeutic drugs,” Lancet Neurology, vol. 2, no. 7, pp. 404–409, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Y. K. Lee, L. D. Lunsford, B. R. Subach, H. D. Jho, D. J. Bissonette, and D. Kondziolka, “Brain surgery with image guidance: current recommendations based on a 20-year assessment,” Stereotactic and Functional Neurosurgery, vol. 75, no. 1, pp. 35–48, 2000. View at Google Scholar · View at Scopus
  16. S. H. Paek, P. B. Audu, M. R. Sperling, J. Cho, and D. W. Andrews, “Reevaluation of surgery for the treatment of brain metastases: review of 208 patients with single or multiple brain metastases treated at one institution with modern neurosurgical techniques,” Neurosurgery, vol. 56, no. 5, pp. 1021–1033, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. A. M. Stark, H. Tscheslog, R. Buhl, J. Held-Feindt, and H. M. Mehdorn, “Surgical treatment for brain metastases: prognostic factors and survival in 177 patients,” Neurosurgical Review, vol. 28, no. 2, pp. 115–119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. W. W. Orrison Jr., “Magnetic source imaging in stereotactic and functional neurosurgery,” Stereotactic and Functional Neurosurgery, vol. 72, no. 2–4, pp. 89–94, 2000. View at Google Scholar
  19. J. D. McDonald, B. W. Chong, J. D. Lewine et al., “Integration of preoperative and intraoperative functional brain mapping in a frameless stereotactic environment for lesions near eloquent cortex: technical note,” Journal of Neurosurgery, vol. 90, no. 3, pp. 591–598, 1999. View at Google Scholar · View at Scopus
  20. R. A. Patchell, P. A. Tibbs, J. W. Walsh et al., “A randomized trial of surgery in the treatment of single metastases to the brain,” New England Journal of Medicine, vol. 322, no. 8, pp. 494–500, 1990. View at Google Scholar · View at Scopus
  21. P. D. Brown, C. A. Brown, B. E. Pollock et al., “Stereotactic radiosurgery for patients with “radioresistant” brain metastases,” Neurosurgery, vol. 51, no. 3, pp. 656–667, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Gaspar, C. Scott, M. Rotman et al., “Recursive Partitioning Analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials,” International Journal of Radiation Oncology Biology Physics, vol. 37, no. 4, pp. 745–751, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. A. H. Mintz, J. Kestle, M. P. Rathbone et al., “A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis,” Cancer, vol. 78, no. 7, pp. 1470–1476, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. C. J. Vecht, H. Haaxma-Reiche, E. M. Noordijk et al., “Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery?” Annals of Neurology, vol. 33, no. 6, pp. 583–590, 1993. View at Publisher · View at Google Scholar · View at Scopus
  25. J. J. Grob, J. Regis, R. Laurans et al., “Radiosurgery without whole brain radiotherapy in melanoma brain metastases,” European Journal of Cancer, vol. 34, no. 8, pp. 1187–1192, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Noël, J. M. Simon, C. A. Valery et al., “Linac radiosurgery for brain metastasis of melanoma,” Stereotactic and Functional Neurosurgery, vol. 79, no. 3-4, pp. 245–255, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Gonzalez-Martinez, L. Hernandez, L. Zamorano et al., “Gamma knife radiosurgery for intracranial metastatic melanoma: a 6-year experience,” Journal of Neurosurgery, vol. 97, no. 5, pp. 494–498, 2002. View at Google Scholar · View at Scopus
  28. K. K. Herfarth, O. Izwekowa, C. Thilmann et al., “Linac-based radiosurgery of cerebral melanoma metastases: analysis of 122 metastases treated in 64 patients,” Strahlentherapie und Onkologie, vol. 179, no. 6, pp. 366–371, 2003. View at Google Scholar · View at Scopus
  29. U. Selek, E. L. Chang, S. J. Hassenbusch et al., “Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases,” International Journal of Radiation Oncology Biology Physics, vol. 59, no. 4, pp. 1097–1106, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. A. E. Radbill, J. F. Fiveash, E. T. Falkenberg et al., “Initial treatment of melanoma brain metastases using gamma knife radiosurgery: an evaluation of efficacy and toxicity,” Cancer, vol. 101, no. 4, pp. 825–833, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Koc, J. McGregor, J. Grecula, C. J. Bauer, N. Gupta, and R. A. Gahbauer, “Gamma Knife radiosurgery for intracranial metastatic melanoma: an analysis of survival and prognostic factors,” Journal of Neuro-Oncology, vol. 71, no. 3, pp. 307–313, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Mindermann, “Tumor recurrence and survival following gamma knife surgery for brain metastases,” Journal of Neurosurgery, vol. 102, pp. 287–288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Wowra, A. Muacevic, A. Jess-Hempen, and J. C. Tonn, “Safety and efficacy of outpatient gamma knife radiosurgery for multiple cerebral metastases,” Expert Review of Neurotherapeutics, vol. 4, no. 4, pp. 673–679, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Stone, J. Cooper, K. L. Koenig, J. G. Golfinos, and R. Oratz, “A comparison of survival rates for treatment of melanoma metastatic to the brain,” Cancer Investigation, vol. 22, no. 4, pp. 492–497, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. A. J. Ulm, W. A. Friedman, F. J. Bova, P. Bradshaw, R. J. Amdur, and W. M. Mendenhall, “Linear accelerator radiosurgery in the treatment of brain metastases,” Neurosurgery, vol. 55, no. 5, pp. 1076–1084, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Gaudy-Marqueste, J. M. Regis, X. Muracciole et al., “Gamma-Knife radiosurgery in the management of melanoma patients with brain metastases: a series of 106 patients without whole-brain radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 65, no. 3, pp. 809–816, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. A. K. Bhatnagar, J. C. Flickinger, D. Kondziolka, and L. D. Lunsford, “Stereotactic radiosurgery for four or more intracranial metastases,” International Journal of Radiation Oncology Biology Physics, vol. 64, no. 3, pp. 898–903, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Manon, A. O'Neill, J. Knisely et al., “Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an eastern cooperative oncology group study (E 6397),” Journal of Clinical Oncology, vol. 23, no. 34, pp. 8870–8876, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Kondziolka, J. J. Martin, J. C. Flickinger et al., “Long-term survivors after gamma knife radiosurgery for brain metastases,” Cancer, vol. 104, no. 12, pp. 2784–2791, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Rao, P. Klimo, C. J. Thompson et al., “Stereotactic radiosurgery as therapy for melanoma, renal carcinoma, and sarcoma brain metastases: impact of added surgical resection and whole-brain radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 66, no. 4, pp. S20–S25, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. D. W. Andrews, C. B. Scott, P. W. Sperduto et al., “Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial,” Lancet, vol. 363, no. 9422, pp. 1665–1672, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. H. Aoyama, H. Shirato, M. Tago et al., “Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial,” Journal of the American Medical Association, vol. 295, no. 21, pp. 2483–2491, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Kocher, R. Soffietti, U. Abacioglu et al., “Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952–26001 study,” Journal of Clinical Oncology, vol. 29, no. 2, pp. 134–141, 2011. View at Publisher · View at Google Scholar
  44. J. S. Loeffler, H. M. Kooy, P. Y. Wen et al., “The treatment of recurrent brain metastases with stereotactic radiosurgery,” Journal of Clinical Oncology, vol. 8, no. 4, pp. 576–582, 1990. View at Google Scholar
  45. G. Noël, M.-A. Proudhom, C.-A. Valery et al., “Radiosurgery for re-irradiation of brain metastasis: results in 54 patients,” Radiotherapy and Oncology, vol. 60, no. 1, pp. 61–67, 2001. View at Publisher · View at Google Scholar
  46. W. E. Samlowski, R. L. Jensen, and D. C. Shrieve, “Multimodality management of brain metastases in metastatic melanoma patients,” Expert Review of Anticancer Therapy, vol. 7, no. 12, pp. 1699–1705, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Mehta, “The dandelion effect: treat the whole lawn or weed selectively?” Journal of Clinical Oncology, vol. 29, no. 2, pp. 121–124, 2011. View at Publisher · View at Google Scholar
  48. E. L. Chang, J. S. Wefel, K. R. Hess et al., “Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial,” The Lancet Oncology, vol. 10, no. 11, pp. 1037–1044, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. S. S. Agarwala, J. M. Kirkwood, M. Gore et al., “Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase II study,” Journal of Clinical Oncology, vol. 22, no. 11, pp. 2101–2107, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Majer, R. L. Jensen, D. C. Shrieve et al., “Biochemotherapy of metastatic melanoma in patients with or without recently diagnosed brain metastases,” Cancer, vol. 110, no. 6, pp. 1329–1337, 2007. View at Publisher · View at Google Scholar · View at Scopus
  51. D. P. Lawrence, O. Hamid, D. F. McDermott et al., “Phase II trial of ipilimumab monotherapy in melanoma patients with brain metastases,” Proceedings of the American Society of Clinical Oncology, vol. 28, no. 15s, abstract 8523, 2010. View at Google Scholar
  52. C. Lebbé, D. F. McDermott, C. Robert et al., “Ipilimumab improves survival in previously treated advanced melanoma patients with poor prognostic factors: subgroup analysis from a phase III trial,” in Proceedings of the 35th ESMO Congress, Milan, Italy, 2010, Abstract 13240, 2010.
  53. K. S. M. Smalley, K. L. Nathanson, and K. T. Flaherty, “Genetic subgrouping of melanoma reveals new opportunities for targeted therapy,” Cancer Research, vol. 69, no. 8, pp. 3241–3244, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. C. D. Van Raamsdonk, V. Bezrookove, G. Green et al., “Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi,” Nature, vol. 457, no. 7229, pp. 599–602, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. C. D. Van Raamsdonk, K. G. Griewank, M. B. Crosby et al., “Mutations in GNA11 in uveal melanoma,” The New England Journal of Medicine, vol. 363, no. 23, pp. 2191–2199, 2010. View at Google Scholar
  56. J. A. Sosman and I. Puzanov, “Molecular targets in melanoma from angiogenesis to apoptosis,” Clinical Cancer Research, vol. 12, no. 7, pp. 2376s–2383s, 2006. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Sharma, N. R. Trivedi, M. A. Zimmerman, D. A. Tuveson, C. D. Smith, and G. P. Robertson, “Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors,” Cancer Research, vol. 65, no. 6, pp. 2412–2421, 2005. View at Publisher · View at Google Scholar · View at Scopus
  58. H. Davies, G. R. Bignell, C. Cox et al., “Mutations of the BRAF gene in human cancer,” Nature, vol. 417, no. 6892, pp. 949–954, 2002. View at Publisher · View at Google Scholar · View at Scopus
  59. A. Hauschild, S. S. Agarwala, U. Trefzer et al., “Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma,” Journal of Clinical Oncology, vol. 27, no. 17, pp. 2823–2830, 2009. View at Publisher · View at Google Scholar · View at Scopus