Table of Contents Author Guidelines Submit a Manuscript
Journal of Skin Cancer
Volume 2012, Article ID 706452, 6 pages
Review Article

Neurotropic Melanoma: The Management of Localised Disease

1Radiation Oncology Queensland, Liz Plummer Cancer Center, Lake and Grove Streets, Cairns, QLD 4870, Australia
2Division of Cancer Services, Princess Alexandra Hospital, University of Queensland, 199 Ipswich Road Woolloongabba, QLD 4102, Australia

Received 6 August 2012; Accepted 23 September 2012

Academic Editor: Giuseppe Argenziano

Copyright © 2012 Jeremy Croker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neurotropic melanoma is a rare subtype of cutaneous malignant melanoma. Compared with conventional melanoma, it is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. These tumours can be a diagnostic dilemma with a variety of morphological, histopathological, and immunophenotypical expressions. The often amelanotic, benign appearance may lead to treatment issues such as late presentation, diagnostic delay, misdiagnosis, insufficient surgical margins, and recurrence with resulting poor outcome. The neurotropic nature of the disease and prevalence in the head and neck region can result in perineural and neural invasion along named large nerves into the brain with resulting neuropathies. Wide local excision with adjuvant radiotherapy where indicated remains the current practice for treatment with chemotherapy predominately being reserved as a salvage treatment for patients with disseminated disease.