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Journal of Skin Cancer
Volume 2012 (2012), Article ID 914267, 7 pages
Review Article

Diagnostic Role of Chromosomal Instability in Melanoma

Department of Dermatology, Anna Fund Melanoma Program, Sylvester Comprehensive Cancer Center and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Room 912, 1501 NW 10th Avenue, Miami, FL 33136-1012, USA

Received 29 June 2012; Revised 20 September 2012; Accepted 21 September 2012

Academic Editor: Lionel Larue

Copyright © 2012 Nitika Dabas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Early diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. There are no current pathological markers to definitively define malignant potential in these indeterminate lesions. Thus, there is a need for improved diagnostic tools. Chromosomal instability (CIN) is a hallmark of cancer and is markedly prevalent in melanoma. Advances in genomics have opened the door for the development of molecular tools to better segregate benign and malignant lesions. This paper focuses on CIN in melanoma and the role of current diagnostic approaches.