Figure 1: Chromosomal abnormalities are prevalent in melanoma. Shown are pairs of representative karyotypes from 3 melanoma lines, DM1N, DM2N, and DM3N revealing heterogeneity between cells within the culture and overall increases (D1 and D3) and decreases in the total number of chromosomes (D2). Single cell clones from these lines will also expand in culture giving rise to cells with different karyotypes (data not shown) suggesting ongoing CIN.