Figure 2: FISH utilizes fluorescent probes to specific areas on chromosomes in cultured cells. Illustrated are OligoFISH probes to the centromeres of chromosomes 2 (yellow), 6 (light blue), 7 (green), and 8 (red). (a) demonstrates the binding to specific chromosomes in a metaphase spread; (b), binding to DNA sequences in a normal diploid human cell, and (c), binding to sequences in a cell with an abnormally increased chromosomal number.