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Journal of Skin Cancer
Volume 2013, Article ID 828329, 8 pages
Clinical Study

Safety and Efficacy of 188-Rhenium-Labeled Antibody to Melanin in Patients with Metastatic Melanoma

1Hadassah Medical Center, Hebrew University, Kiryat Hadassah, 91120 Jerusalem, Israel
2Chaim Sheba Medical Center, Tel Hashomer, 52621 Ramat Gan, Israel
3Sackler Faculty of Medicine, Tel Aviv Medical Center, 69978 Tel Aviv, Israel
4Rambam Health Care Campus, 31096 Haifa, Israel
5Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
6Pain Therapeutics, Inc., Austin, TX 78731, USA
7Davis Medical Center, University of California, Sacramento, CA 95817, USA

Received 13 July 2012; Accepted 10 December 2012

Academic Editor: Silvia Moretti

Copyright © 2013 M. Klein et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure S1 shows the waterfall plot of the best percentage change from baseline of the sum of the longest diameters (SLD) for the target lesions.

Supplementary Table S1 shows the effective and biological half-lives of 188Re-6D2 mAb in MM patients.

Supplementary Table S2 shows the RECIST overall response and lesion response at week 6 post-treatment visit.

Supplementary Table S3 shows the HAMA response from phase 1a and phase 1b studies.

Supplementary Table S4 shows the summary of adverse effects (AE).

  1. Supplementary Materials