Kaposi’s Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis
Figure 1
KSHV infection of primary melanocytes and melanoma-derived cells is associated with virus-induced morphological changes. (a) (b): Representative phase and GFP images of uninfected (a) or rKSHV.219-infected (b) primary NHEM-Ad melanocytes at day two after infection. Rightmost panels are enlarged (20x) phase contrast views of uninfected and infected cultures, respectively. (c) (d): Representative images of uninfected or rKSHV.219-infected MeWo cells (c) and Mel1700 cells (d). Multinucleated cells in infected MeWo cells are denoted with asterisks, whereas yellow arrows in infected Mel1700 cells point to elongated dendritic spines putatively induced by the virus.
