Dual S-100-AE1/3 Immunohistochemistry to Detect Perineural Invasion in Nonmelanoma Skin Cancers

Figure 3

Perineural invasion. A small nerve branch (red) completely surrounded by squamous cell carcinoma (brown) in a case in which perineural invasion was not detected on H&E. IHC with dual staining for S-100 and AE1/3, original magnification ×200. H&E: hematoxylin and eosin; IHC: immunohistochemistry.