Microvessel Density in Patients with Cutaneous Melanoma: An Up-to-Date Systematic Review and Meta-Analysis

Table 1

Included studies.

PMID	Author	Type of study	Year	Country	Center	Sample (patients)	Analysis sample	Specimens	Age	Gender (male/female)	Follow-up
12115882	Döme et al.	Prospective	2002	Hungary	Single centre	45	45	45 melanomas, 4 nontumorous skin biopsy samples, 3 naevi	n/a	n/a	>5 years
17013095	Hillen et al.	Retrospective	2006	Netherlands	Single centre	58	58	58	52.69 (5.5)	18 (31%)/40 (69%)	10 years
10465583	Ilmonen et al.	Retrospective	1999	Finland	Single centre	84	84	84	54.2 (11.233)	42 (50%)/42 (50%)	4.05–4.54 years
11942572	Massi et al.	Retrospective	2002	Italy	Single centre	45	45	45	Cases: 56 (8) Controls: n/a	22 (48.9%)/23 (51.1%)	Cases: 154 (21.75) months Controls: 94 (22.25) months
26264662	Pastushenko et al.	Retrospective	2015	Spain	Multicentre	196	196	196	65.2 (12.466)	103 (52.55%)/89 (45.4%)	2.7 (2.1) years
12760367	Ribatti et al.	Prospective	2003	Italy	Single centre	25	25	25	22–84	10 (40%)/15 (60%)	4-5 years
26237765	Shimizu et al.	Retrospective	2015	Japan	Single centre	128	128	158 (128 melanomas and 30 resected melanocytic naevi)	63 (12)	65 (50.78%)/63 (49.22%)	1759 days (1,221.33)
11438469	Straume et al.	Retrospective	2001	Norway	Single centre	202	174	270 (202 VGP melanomas and 68 metastases)	n/a	n/a	76 months (32.833)
14746853	Valencak et al.	Retrospective	2004	Austria	Single centre	120	120	120	57.13 (10.33)	n/a	44.6 months (15.56)