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Journal of Skin Cancer
Volume 2017, Article ID 2692604, 10 pages
Review Article

The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma

Faculty of Medicine, Tarumanagara University, Jl. Letjen S. Parman No. 1, Jakarta 11440, Indonesia

Correspondence should be addressed to Anthony Paulo Sunjaya; moc.oohay@yjsynohtna

Received 3 August 2017; Revised 3 November 2017; Accepted 29 November 2017; Published 31 December 2017

Academic Editor: Mark Lebwohl

Copyright © 2017 Anthony Paulo Sunjaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Basal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3–10% increase in incidence each year. The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year. BCC needs to be detected at the early stages to prevent local destruction causing disabilities to patients and increasing treatment costs. Furthermore, BCC patients who have undergone surgery are still at risk for recurrence, especially when the surgery performed fails to remove all the BCC cells, even when conventional histopathological testing after surgery has reported a surgically free margin. This review aims to evaluate studies on the use of BerEP4 immunohistochemistry staining on pathological sections of various types of BCC as well as its shortfalls. BerEP4 is a monoclonal antibody which detects specific epithelial-glycoprotein-adhesion-molecules (EpCAM) found on BCC cells. Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells. The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery.