Journal of Skin Cancer / 2019 / Article / Tab 1

Research Article

Immunohistochemical Analysis of BRAF (V600E) Mutation and P16 Expression in Malignant Melanoma in Lagos, Nigeria: A 10-Year Retrospective Study

Table 1

Correlation between P16 expression and prognostic factors.

Variables P16p value
POSITIVE  
n=14(%)
NEGATIVE  
n=31(%)

Age group (years)
 <402 (40)3 (60)0.123
 40-497 (54)6 (46)
 50-591 (14)7 (86)
 60-694(33)8 (67)
 ≥700(0)7(100)
Clark’s Stage
 I0(0)0(0)0.627
 II0(0)0(0)
 III2(40)3(60)
 IV6(25)18(75)
 V5(45)8(55)
Breslow thickness
 <4mm1(14)6(86)0.405
 ≥4mm12 (36)23(64)
Ulceration
 Absent4(25)12(75)0.282
 Present9(35)17(65)

Variant (Cutaneous MM)n=10n=27
Acral lentiginous2(50)2(50)0.064
Desmoplastic1(100)0(0)
Nodular7(22)25(88)

1 lymph node was P16 positive, while 2 were P16 negative. Histologic variant applies only to cutaneous MM, n = 37.

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