Immunohistochemical Analysis of BRAF (V600E) Mutation and P16 Expression in Malignant Melanoma in Lagos, Nigeria: A 10-Year Retrospective Study

Table 1

Correlation between P16 expression and prognostic factors.

Variables	P16		p value
	POSITIVE; n=14(%)	NEGATIVE; n=31(%)
Age group (years)
<40	2 (40)	3 (60)	0.123
40-49	7 (54)	6 (46)
50-59	1 (14)	7 (86)
60-69	4(33)	8 (67)
≥70	0(0)	7(100)
Clark’s Stage
I	0(0)	0(0)	0.627
II	0(0)	0(0)
III	2(40)	3(60)
IV	6(25)	18(75)
V	5(45)	8(55)
Breslow thickness
<4mm	1(14)	6(86)	0.405
≥4mm	12 (36)	23(64)
Ulceration
Absent	4(25)	12(75)	0.282
Present	9(35)	17(65)
Variant (Cutaneous MM)	n=10	n=27
Acral lentiginous	2(50)	2(50)	0.064
Desmoplastic	1(100)	0(0)
Nodular	7(22)	25(88)

1 lymph node was P16 positive, while 2 were P16 negative. Histologic variant applies only to cutaneous MM, n = 37.