Risk Factors for Developing Nonmelanoma Skin Cancer after Lung Transplantation

Table 4

Binary logistic regression of risk factors for NMSC or precancerous lesions after lung transplantation.

	OR (95% CI)
Variable	Univariate Analysis	P value	Multivariable Analysi	P value
Male sex	2.41 (0.99 – 5.88)	.05	4.01 (1.43 – 11.22)	.008
Higher age at first lung transplantation, y	1.04 (0.99 – 1.09)	.06	1.06 (1.01 – 1.12)	.02
Fair ski	2.27 (0.87 – 5.88)	.09	3.01 (1.02 – 8.93)	.0
Time of voriconazole exposure,	1.06 (0.99 – 1.14)	.11	1.11 (1.00 – 1.23)	.04
High UV exposure after LTx	0.60 (0.30 – 1.20)	.15	0.76 (0.33 – 1.72)	.50
Minimal sunscreen usage before LTx	1.10 (0.44 – 2.75)	.84	NA	NA
High UV exposure before LTx	0.86 (0.45 – 1.66)	.65	NA	NA
Minimal sunscreen usage after LTX	2.19 (0.61 – 7.81)	.23	NA	NA
Immunosuppression without everolimu	1.27 (0.43 – 3.78)	.66	NA	NA

OR, odds ratio; CI, confidence interval; UV, ultra violet; NA, not applicable.
The final model exhibited an overall significance (P=.001, Nagelkerkes R²=.27).
Representing Fitzpatrick skin types I and II.
P=.047.
Calculated cumulating all periods of voriconazole intake.
Patients not continuously receiving everolimus from LTx to dermatologic examination.