MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A

Figure 5

MDM4 isoform expression in melanocytic lesions is dramatically different from normal skin. Isoform-specific expression data were compared for 120 patient-derived xenografts. (a) Expression of the alternative transcript MDM4-A is significantly greater than the expression of the full-length MDM4 transcript in these specimens (Students’ t-test value = 1.386 × 10⁻¹³). (b) In contrast, MDM2 expression is almost entirely the full-length transcript designated as MDM2-A. (c) Analysis of 30 clinical melanoma specimens and 10 melanocytic benign nevi by isoform-specific RT-PCR.

(a)

(b)

(c)