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Spectroscopy
Volume 13, Issue 2, Pages 145-150
http://dx.doi.org/10.1155/1997/406493

Matrix-assisted laser desorption ionization and electrospray ionization combined with Fourier transform ion cyclotron resonance mass spectrometry

Paul O. Staneke and Nico M. M. Nibbering

Institute of Mass Spectrometry, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands

Received 1 October 1996

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

During recent years, matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI) are successfully employed to analyze biomolecules and polymers. In combination with Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry, high mass resolution and mass measurement accuracy can be achieved to enable the determination of molecular weights and structural characterization of biochemical compounds larger than 10 kDa.