Table of Contents Author Guidelines Submit a Manuscript
Spectroscopy
Volume 18 (2004), Issue 1, Pages 31-36
http://dx.doi.org/10.1155/2004/376572

Electrospray ion mobility spectrometry of intact viruses

John J. Thomas,1 Brian Bothner,1 Joe Traina,2 W. Henry Benner,3 and Gary Siuzdak1

1The Scripps Research Institute, Center for Mass Spectrometry and Department of Molecular Biology, 10550 N. Torrey Pines Rd., La Jolla, CA-92037, USA
2Berlex Biosciences, Richmond, CA-94806, USA
3Lawrence Livermore National Lab, Livermore, CA-94551, USA

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [63 citations]

The following is the list of published articles that have cited the current article.

  • Brian Bothner, and Gary Siuzdak, “Electrospray ionization of a whole virus: Analyzing mass, structure, and viability,” ChemBioChem, vol. 5, no. 3, pp. 258–260, 2004. View at Publisher · View at Google Scholar
  • Robert H.H. Van Den Heuvel, and Albert J.R. Heck, “Native protein mass spectrometry: From intact oligomers to functional machineries,” Current Opinion in Chemical Biology, vol. 8, no. 5, pp. 519–526, 2004. View at Publisher · View at Google Scholar
  • C.J. Hogan, E.M. Kettleson, M.-H. Lee, B. Ramaswami, L.T. Angenent, and P. Biswas, “Sampling methodologies and dosage assessment techniques for submicrometre and ultrafine virus aerosol particles,” Journal of Applied Microbiology, vol. 99, no. 6, pp. 1422–1434, 2005. View at Publisher · View at Google Scholar
  • Justin L.P. Benesch, J. Andrew Aquilina, Brandon T. Ruotolo, Frank Sobott, and Carol V. Robinson, “Tandem Mass Spectrometry Reveals the Quaternary Organization of Macromolecular Assemblies,” Chemistry and Biology, vol. 13, no. 6, pp. 597–605, 2006. View at Publisher · View at Google Scholar
  • Christopher J. Hogan Jr., Eric M. Kettleson, Bala Ramaswami, Da-Ren Chen, and Pratim Biswas, “Charge reduced electrospray size spectrometry of mega- and gigadalton complexes: Whole viruses and virus fragments,” Analytical Chemistry, vol. 78, no. 3, pp. 844–852, 2006. View at Publisher · View at Google Scholar
  • Zongxiu Nie, Yan-Kai Tzeng, Huan-Cheng Chang, Chi-Chien Chiu, Chi-Yao Chang, Chia-Ming Chang, and Mi-Hua Tao, “Microscopy-Based Mass Measurement of a Single Whole Virus in a Cylindrical Ion Trap,” Angewandte Chemie, vol. 118, no. 48, pp. 8311–8314, 2006. View at Publisher · View at Google Scholar
  • Zongxiu Nie, Yan-Kai Tzeng, Huan-Cheng Chang, Chi-Chien Chiu, Chi-Yao Chang, Chia-Ming Chang, and Mi-Hua Tao, “Microscopy-Based Mass Measurement of a Single Whole Virus in a Cylindrical Ion Trap,” Angewandte Chemie International Edition, vol. 45, no. 48, pp. 8131–8134, 2006. View at Publisher · View at Google Scholar
  • R. O. Sokolovskii, M. Thachuk, and G. N. Patey, “Tracer diffusion in hard sphere fluids from molecular to hydrodynamic regimes,” The Journal of Chemical Physics, vol. 125, no. 20, pp. 204502, 2006. View at Publisher · View at Google Scholar
  • Catherine S. Kaddis, Shirley H. Lomeli, Sheng Yin, Beniam Berhane, Marcin I. Apostol, Valerie A. Kickhoefer, Leonard H. Rome, and Joseph A. Loo, “Sizing Large Proteins and Protein Complexes by Electrospray Ionization Mass Spectrometry and Ion Mobility,” Journal of the American Society for Mass Spectrometry, vol. 18, no. 7, pp. 1206–1216, 2007. View at Publisher · View at Google Scholar
  • Jian He, Wenwan Zhong, Aijun Tang, Xiaomei Yan, Cris Lewis, Vahid Majidi, and Wei Hang, “A fluorescence detection scheme for ultra large molecules after gas phase separation,” Talanta, vol. 71, no. 5, pp. 2126–2128, 2007. View at Publisher · View at Google Scholar
  • I. Wuled Lenggoro, Hendri Widiyandari, Christopher J. Hogan, Pratim Biswas, and Kikuo Okuyama, “Colloidal nanoparticle analysis by nanoelectrospray size spectrometry with a heated flow,” Analytica Chimica Acta, vol. 585, no. 2, pp. 193–201, 2007. View at Publisher · View at Google Scholar
  • Kasinath Viswanathan, and Klaus Früh, “Viral proteomics: global evaluation of viruses and their interaction with the host,” Expert Review of Proteomics, vol. 4, no. 6, pp. 815–829, 2007. View at Publisher · View at Google Scholar
  • Petr Novak, and Anastassios E. Giannakopulos, “Chemical cross-linking and mass spectrometry as structure determination tools,” European Journal of Mass Spectrometry, vol. 13, no. 2, pp. 105–113, 2007. View at Publisher · View at Google Scholar
  • Chiara Carazzone, Reingard Raml, and Spiros A. Pergantis, “Nanoelectrospray ion mobility spectrometry online with inductively coupled plasma-mass spectrometry for sizing large proteins, DNA, and nanoparticles,” Analytical Chemistry, vol. 80, no. 15, pp. 5812–5818, 2008. View at Publisher · View at Google Scholar
  • Michael P. Caulfield, Shuguang Li, Gloria Lee, Patricia J. Blanche, Wael A. Salarneh, W. Henry Benner, Richard E. Reitz, and Ronald M. Krauss, “Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis,” Clinical Chemistry, vol. 54, no. 8, pp. 1307–1316, 2008. View at Publisher · View at Google Scholar
  • Günter Allmaier, Christian Laschober, and Wladyslaw W. Szymanski, “Nano ES GEMMA and PDMA, New Tools for the Analysis of Nanobioparticles-Protein Complexes, Lipoparticles, and Viruses,” Journal of the American Society for Mass Spectrometry, vol. 19, no. 8, pp. 1062–1068, 2008. View at Publisher · View at Google Scholar
  • Christopher J. Hogan Jr., and Pratim Biswas, “Narrow size distribution nanoparticle production by electrospray processing of ferritin,” Journal of Aerosol Science, vol. 39, no. 5, pp. 432–440, 2008. View at Publisher · View at Google Scholar
  • Wen-Ping Peng, Huan-Chang Lin, Ming-Lee Chu, Huan-Cheng Chang, Hsin-Hung Lin, Alice L. Yu, and Chung-Hsuan Chen, “Charge monitoring cell mass spectrometry,” Analytical Chemistry, vol. 80, no. 7, pp. 2524–2530, 2008. View at Publisher · View at Google Scholar
  • Christian Laschober, Juergen Wruss, Dieter Blaas, Wladyslaw W. Szymanski, and Günter Allmaier, “Gas-phase electrophoretic molecular mobility analysis of size and stoichiometry of complexes of a common cold virus with antibody and soluble receptor molecules,” Analytical Chemistry, vol. 80, no. 6, pp. 2261–2264, 2008. View at Publisher · View at Google Scholar
  • Victoria L. Morton, Peter G. Stockley, Nicola J. Stonehouse, and Alison E. Ashcroft, “Insights into virus capsid assembly from non-covalent mass spectrometry,” Mass Spectrometry Reviews, vol. 27, no. 6, pp. 575–595, 2008. View at Publisher · View at Google Scholar
  • Kenneth D. Cole, Leonard F. Pease, De-Hao Tsai, Tania Singh, Scott Lute, Kurt A. Brorson, and Lili Wang, “Particle concentration measurement of virus samples using electrospray differential mobility analysis and quantitative amino acid analysis,” Journal Of Chromatography A, vol. 1216, no. 30, pp. 5715–5722, 2009. View at Publisher · View at Google Scholar
  • Kelvin Wong, Irene Xagoraraki, James Wallace, William Bickert, Sangeetha Srinivasan, and Joan B. Rose, “Removal of viruses and indicators by anaerobic membrane bioreactor treating animal waste,” Journal of Environmental Quality, vol. 38, no. 4, pp. 1694–1699, 2009. View at Publisher · View at Google Scholar
  • Jae Hee Jung, Jung Eun Lee, and Sang Soo Kim, “Generation of nonagglomerated airborne bacteriophage particles using an electrospray technique,” Analytical Chemistry, vol. 81, no. 8, pp. 2985–2990, 2009. View at Publisher · View at Google Scholar
  • Bryan J. McCullough, and Simon J. Gaskell, “Using electrospray ionisation mass spectrometry to study non-covalent interactions,” Combinatorial Chemistry and High Throughput Screening, vol. 12, no. 2, pp. 203–211, 2009. View at Publisher · View at Google Scholar
  • Leonard F. Pease III, Daniel I. Lipin, De-Hao Tsai, Michael R. Zachariah, Linda H. L. Lua, Michael J. Tarlov, and Anton P. J. Middelberg, “Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy,” Biotechnology and Bioengineering, vol. 102, no. 3, pp. 845–855, 2009. View at Publisher · View at Google Scholar
  • David P. Smith, Tom W. Knapman, Lain Campuzano, Richard W. Malham, Joshua T. Berryman, Sheena E. Radford, and Alison E. Ashcroft, “Deciphering drift time measurements from travelling wave ion mobility spectrometry- Mass spectrometry studies,” European Journal of Mass Spectrometry, vol. 15, no. 2, pp. 113–130, 2009. View at Publisher · View at Google Scholar
  • Robert M. Eninger, Christopher J. Hogan, Pratim Biswas, Atin Adhikari, Tiina Reponen, and Sergey A. Grinshpun, “Electrospray versus Nebulization for Aerosolization and Filter Testing with Bacteriophage Particles,” Aerosol Science and Technology, vol. 43, no. 4, pp. 298–304, 2009. View at Publisher · View at Google Scholar
  • Leonard F. Pease, De-Hao Tsai, Joshua L. Hertz, Rebecca A. Zangmeister, Michael R. Zachariah, and Michael J. Tarlov, “Packing and size determination of colloidal nanoclusters,” Langmuir, vol. 26, no. 13, pp. 11384–11390, 2010. View at Publisher · View at Google Scholar
  • Alexander Bunkowski, “Software tool for coupling chromatographic total ion current dependencies of GC/MSD and MCC/IMS,” International Journal for Ion Mobility Spectrometry, vol. 13, no. 3, pp. 169–175, 2010. View at Publisher · View at Google Scholar
  • Leonard F. Pease, Jeeseong Hwang, Jeremy I. Feldblyum, Silvia H. Depaoli Lacaerda, Yonglin Liu, Angela R. Hight Walker, Rajasekhar Anumolu, Peter B. Yim, Matthew L. Clarke, and Hyeong Gon Kang, “Structural analysis of soft multicomponent nanoparticle clusters,” ACS Nano, vol. 4, no. 11, pp. 6982–6988, 2010. View at Publisher · View at Google Scholar
  • Jae Hee Jung, Jung Eun Lee, Gi Byoung Hwang, Byung Uk Lee, Seung Bok Lee, Jong Soo Jurng, and Gwi Nam Bae, “Electrospray-assisted ultraviolet aerodynamic particle sizer spectrometer for real-time characterization of bacterial particles,” Analytical Chemistry, vol. 82, no. 2, pp. 664–671, 2010. View at Publisher · View at Google Scholar
  • Toshiki Sugai, “Fundamentals of Mass Spectrometry,” Journal of the Mass Spectrometry Society of Japan, vol. 58, no. 2, pp. 47–73, 2010. View at Publisher · View at Google Scholar
  • Fabris, “MS analysis of nucleic acids in the post-genomic era,” Analytical Chemistry, vol. 83, no. 15, pp. 5810–5816, 2011. View at Publisher · View at Google Scholar
  • Luis B. Modesto-Lopez, Eric M. Kettleson, and Pratim Biswas, “Soft X-ray charger (SXC) system for use with electrospray for mobility measurement of bioaerosols,” Journal of Electrostatics, vol. 69, no. 4, pp. 357–364, 2011. View at Publisher · View at Google Scholar
  • Charlotte Uetrecht, and Albert J. R. Heck, “Moderne biomolekulare Massenspektrometrie und ihre Bedeutung für die Erforschung der Struktur, der Dynamik und des Aufbaus von Viren,” Angewandte Chemie, vol. 123, no. 36, pp. 8398–8413, 2011. View at Publisher · View at Google Scholar
  • Kapellios, Karamanou, Sardis, Aivaliotis, Economou, and Pergantis, “Using nanoelectrospray ion mobility spectrometry (GEMMA) to determine the size and relative molecular mass of proteins and protein assemblies: A comparison with MALLS and QELS,” Analytical and Bioanalytical Chemistry, vol. 399, no. 7, pp. 2421–2433, 2011. View at Publisher · View at Google Scholar
  • András Kiss, and Ron M. A. Heeren, “Size, weight and position: Ion mobility spectrometry and imaging MS combined,” Analytical and Bioanalytical Chemistry, vol. 399, no. 8, pp. 2623–2634, 2011. View at Publisher · View at Google Scholar
  • Leonard F. Pease, De-Hao Tsai, Kurt A. Brorson, Suvajyoti Guha, Michael R. Zachariah, and Michael J. Tarlov, “Physical characterization of icosahedral virus ultra structure, stability, and integrity using electrospray differential mobility analysis,” Analytical Chemistry, vol. 83, no. 5, pp. 1753–1759, 2011. View at Publisher · View at Google Scholar
  • Suvajyoti Guha, Leonard F. Pease, Kurt A. Brorson, Michael J. Tarlov, and Michael R. Zachariah, “Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing,” Journal of Virological Methods, vol. 178, no. 1-2, pp. 201–208, 2011. View at Publisher · View at Google Scholar
  • Xing Zhang, and Ryan R. Julian, “Investigating the gas phase structure of KIX with radical directed dissociation and molecular dynamics: Retention of the native structure,” International Journal of Mass Spectrometry, vol. 308, no. 2-3, pp. 225–231, 2011. View at Publisher · View at Google Scholar
  • Charlotte Uetrecht, and Albert J. R. Heck, “Modern Biomolecular Mass Spectrometry and its Role in Studying Virus Structure, Dynamics, and Assembly,” Angewandte Chemie-International Edition, vol. 50, no. 36, pp. 8248–8262, 2011. View at Publisher · View at Google Scholar
  • Marelize Botes, Michéle Kwaadsteniet, and Thomas Eugene Cloete, “Application of quantitative PCR for the detection of microorganisms in water,” Analytical and Bioanalytical Chemistry, vol. 405, no. 1, pp. 91–108, 2012. View at Publisher · View at Google Scholar
  • Kelvin Wong, Theng-Theng Fong, Kyle Bibby, and Marirosa Molina, “Application of enteric viruses for fecal pollution source tracking in environmental waters,” Environment International, vol. 45, pp. 151–164, 2012. View at Publisher · View at Google Scholar
  • Jonathan T. S. Hopper, Andrew Rawlings, José P. Afonso, Deborah Channing, Robert Layfield, and Neil J. Oldham, “Evidence for the Preservation of Native Inter- and Intra-Molecular Hydrogen Bonds in the Desolvated FK-Binding Protein·FK506 Complex Produced by Electrospray Ionization,” Journal of The American Society for Mass Spectrometry, vol. 23, no. 10, pp. 1757–1767, 2012. View at Publisher · View at Google Scholar
  • Suvajyoti Guha, Mingdong Li, Michael J. Tarlov, and Michael R. Zachariah, “Electrospray–differential mobility analysis of bionanoparticles,” Trends in Biotechnology, vol. 30, no. 5, pp. 291–300, 2012. View at Publisher · View at Google Scholar
  • Gillian R. Hilton, and Justin L. P. Benesch, “Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry,” Journal of the Royal Society Interface, vol. 9, no. 70, pp. 801–816, 2012. View at Publisher · View at Google Scholar
  • Leonard F. Pease, “Physical analysis of virus particles using electrospray differential mobility analysis,” Trends in Biotechnology, vol. 30, no. 4, pp. 216–224, 2012. View at Publisher · View at Google Scholar
  • Samuel I. Merenbloom, Tawnya G. Flick, and Evan R. Williams, “How hot are your ions in TWAVE ion mobility spectrometry?,” Journal of the American Society for Mass Spectrometry, vol. 23, no. 3, pp. 553–562, 2012. View at Publisher · View at Google Scholar
  • Shu Li, Jian Jia, Xiaoguang Gao, Xiuli He, and Jianping Li, “Analysis of antibiotics from liquid sample using electrospray ionization-ion mobility spectrometry,” Analytica Chimica Acta, vol. 720, pp. 97–103, 2012. View at Publisher · View at Google Scholar
  • Yueyang Zhong, Suk-Joon Hyung, and Brandon T Ruotolo, “Ion mobility–mass spectrometry for structural proteomics,” Expert Review of Proteomics, vol. 9, no. 1, pp. 47–58, 2012. View at Publisher · View at Google Scholar
  • Amanda C. MacMillan, John B. Morrison, Christopher W. Harmon, and Sergey A. Nizkorodov, “Enhancement of surfactants in nanoparticles produced by an electrospray aerosol generator,” Aerosol Science and Technology, vol. 46, no. 11, pp. 1239–1245, 2012. View at Publisher · View at Google Scholar
  • Jessica Z. Bereszczak, Marlene Havlik, Victor U. Weiss, Martina Marchetti-Deschmann, Esther Duijn, Norman R. Watts, Paul T. Wingfield, Guenter Allmaier, Alasdair C. Steven, and Albert J. R. Heck, “Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: morphology selective binding of Fabs to hepatitis B virus capsids,” Analytical and Bioanalytical Chemistry, 2013. View at Publisher · View at Google Scholar
  • Yen-Hsun Tseng, and Leonard F. Pease, “Electrospray differential mobility analysis for nanoscale medicinal and pharmaceutical applications,” Nanomedicine: Nanotechnology, Biology and Medicine, 2014. View at Publisher · View at Google Scholar
  • Sara N. Pratt, and Daniel E. Austin, “Bacterial Spores Survive Electrospray Charging and Desolvation,” Journal of The American Society for Mass Spectrometry, 2014. View at Publisher · View at Google Scholar
  • Kaveh Amini, and Heinz-Bernhard Kraatz, “Recent advances and developments in monitoring biological agents in water samples,” Reviews in Environmental Science and Bio/Technology, 2014. View at Publisher · View at Google Scholar
  • Marlene Havlik, Martina Marchetti-Deschmann, Gernot Friedbacher, Paul Messner, Wolfgang Winkler, Laura Perez-Burgos, Christa Tauer, and Günter Allmaier, “Development of a bio-analytical strategy for characterization of vaccine particles combining SEC and nanoES GEMMA,” The Analyst, vol. 139, no. 6, pp. 1412, 2014. View at Publisher · View at Google Scholar
  • Victor U. Weiss, Jessica Z. Bereszcazk, Marlene Havlik, Peter Kallinger, Irene Gösler, Mohit Kumar, Dieter Blaas, Martina Marchetti-Deschmann, Albert J. R. Heck, Wladyslaw W. Szymanski, and Günter Allmaier, “Analysis of a Common Cold Virus and Its Subviral Particles by Gas-Phase Electrophoretic Mobility Molecular Analysis and Native Mass Spectrometry,” Analytical Chemistry, pp. 150812090645003, 2015. View at Publisher · View at Google Scholar
  • Elizabeth E. Pierson, David Z. Keifer, Alexander A. Kukreja, Joseph C.-Y. Wang, Adam Zlotnick, and Martin F. Jarrold, “Charge Detection Mass Spectrometry Identifies Preferred Non-Icosahedral Polymorphs in the Self-Assembly of Woodchuck Hepatitis Virus Capsids,” Journal of Molecular Biology, 2015. View at Publisher · View at Google Scholar
  • Elizabeth E. Pierson, David. Z. Keifer, Aravind Asokan, and Martin F. Jarrold, “Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry,” Analytical Chemistry, 2016. View at Publisher · View at Google Scholar
  • David Z. Keifer, Tina Motwani, Carolyn M. Teschke, and Martin F. Jarrold, “Acquiring Structural Information on Virus Particles with Charge Detection Mass Spectrometry,” Journal of The American Society for Mass Spectrometry, 2016. View at Publisher · View at Google Scholar
  • Seongho Jeon, Derek R. Oberreit, Gary Van Schooneveld, and Christopher J. Hogan, “Nanomaterial size distribution analysis via liquid nebulization coupled with ion mobility spectrometry (LN-IMS),” The Analyst, vol. 141, no. 4, pp. 1363–1375, 2016. View at Publisher · View at Google Scholar
  • Günter Allmaier, Dieter Blaas, Christina Bliem, Thomas Dechat, Sofiya Fedosyuk, Irene Gösler, Heinrich Kowalski, and Victor U. Weiss, “Monolithic Anion-Exchange Chromatography Yields Rhinovirus of High Purity,” Journal of Virological Methods, 2017. View at Publisher · View at Google Scholar
  • Daniel N. Mortensen, Anna C. Susa, and Evan R. Williams, “Collisional Cross-Sections with T-Wave Ion Mobility Spectrometry without Experimental Calibration,” Journal of The American Society for Mass Spectrometry, 2017. View at Publisher · View at Google Scholar