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Volume 18, Issue 3, Pages 485-500

Preliminary study on the synthesis and high‒resolution NMR analysis of Naproxen and Ibuprofen esters

Christopher K. Jankowski,1 Gaetan LeClair,1 André Aumélas,1 Mario Gonzalez-de la Parra,2 Manuel Jimenez-Estrada,2 Veronica Tejada,2 Ricardo Chilpa-Reyes,2 Jacqueline M. R. Bélanger,3 and J. R. Jocelyn Paré3

1Département de Chimie et Biochimie, Université de Moncton, Moncton, NB, E1A 3E9, Canada
2Instituto de Quimica and Departamento de Farmacia, Faculdad de Quimica, UNAM, Cd. Universitaria Circuito Exterior, 04510 Mexico, DF, Mexico
3Microwave-Assisted Process Division, Environment Canada, Ottawa, ON, K1A 0H3, Canada

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The synthesis and NMR analysis of several diastereoisomeric Naproxyl–Naproxenate, Naproxyl–Ibuprofenate and Ibuprofyl–Naproxenate esters are reported. The NMR high resolution spectra run in presence of the chiral shift reagents and variable temperature analysis were done to study the dynamic properties of these esters.