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Volume 18, Issue 3, Pages 459-467

Infrared spectroscopic study of triacetyl‒β‒cyclodextrin and its inclusion complex with nicardipine

I. Bratu,1 F. Veiga,2 C. Fernandes,2 A. Hernanz,3 and J. M. Gavira3

1National Institute for Research and Development of Isotopic and Molecular Technologies, P.O. Box 700, R-3400 Cluj-Napoca 5, Romania
2Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
3Universidad Nacional de Educación a Distancia, Departamento de Ciencias y Tecnicas Fίsico Quimicas, Senda del Rey 9, 28040 Madrid, Spain

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Infrared spectra of inclusion compounds of triacetyl‒β‒cyclodextrin with nicardipine hydrochloride were compared and analysed with those corresponding to their physical mixture and the pure compounds, respectively. Different O–H stretching vibrations, assigned to water molecules, were located in the Fourier Transform Infrared (FT IR) spectra of triacetyl‒β‒cyclodextrin, and its inclusion complex with nicardipine obtained by spray‒drying (SD) method. Water molecules involved in various hydrogen bonds environments change their status during complexation process. Evidences are observed of the formation of the complex especially in the spectral regions of the amino and carbonyl stretching vibrations.