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Volume 18, Issue 1, Pages 13-29

High resolution nuclear magnetic resonance spectroscopy-guided mutagenesis for characterization of membrane-bound proteins: Experimental designs and applications

Ke-He Ruan

Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [3 citations]

The following is the list of published articles that have cited the current article.

  • Lihai Zhang, Gangxiong Huang, Jiaxin Wu, and Ke-He Ruan, “A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis,” Biochemistry, vol. 44, no. 34, pp. 11389–11401, 2005. View at Publisher · View at Google Scholar
  • Hironari Akasaka, Natasha Thaliachery, Xianghai Zheng, Marissa Blumenthal, Sameer Nikhar, Emma E. Murdoch, Qinglan Ling, and Ke-He Ruan, “The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2-and retaining PGE1-mediated signaling in live cells,” Archives of Biochemistry and Biophysics, 2017. View at Publisher · View at Google Scholar
  • Yan Li, Anna Xu, Qinglan Ling, and Ke-He Ruan, “Advances in extracellular ligand recognition sites on prostanoid receptors,” Future Medicinal Chemistry, 2018. View at Publisher · View at Google Scholar