Journal of Spectroscopy

Journal of Spectroscopy / 2007 / Article

Open Access

Volume 21 |Article ID 131582 |

Chang-yun Chen, Xiao-tian Gu, Jia-hong Zhou, "Binding studies of paeonolum with bovine serum albumin using spectroscopic methods", Journal of Spectroscopy, vol. 21, Article ID 131582, 8 pages, 2007.

Binding studies of paeonolum with bovine serum albumin using spectroscopic methods


Fluorescence and UV spectroscopic techniques were used to investigate the interaction of Paeonolum, one of the major bioactive components isolated from the bark of peony plant, with bovine serum albumin (BSA). Results obtained reveal that a binding interaction occurs between paeonolum and BSA under physiological conditions, and the interaction can quench the fluorescence of BSA originating from the complex formation between paeonolum and BSA. In addition, according to the thermodynamics parameters of this interaction process, it appears that this binding interaction is mainly hydrophobic in nature.

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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