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Volume 22 (2008), Issue 2-3, Pages 177-185

The investigations of bioactive copper(II) complexes with reduced low-molar dextran

Milorad Cakić,1 Žarko Mitić,2,4 Goran S. Nikolić,1 Ljubomir Ilić,3 and Goran M. Nikolić2

1Faculty of Technology, University of Niš, Leskovac, Serbia
2Faculty of Medicine, Department of Pharmacy, University of Niš, Niš, Serbia
3Pharmaceutical and Chemical Industry “Zdravlje Actavis Co.”, Leskovac, Serbia
4Faculty of Medicine, Department of Pharmacy, Bul. dr. Zorana Đinđića 81, 18000 Niš, Serbia

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The optimization of the reaction conditions (pH, T, t) to obtain stable copper(II) ion complexes with dextran derivatives were investigated in this paper. A complete synthesis of stable aqueous complexes can be realized with reduced low-molar polysaccharides, at an average molar mass 5000 g mol–1 and pH 7.5–8. Fourier-transform IR spectra of polysaccharide dextran and its compounds with copper(II) ion, recorded at room temperature, were analyzed in order to obtain the information about the structure and the conformation of these polymer compounds. The ESR parameters of the spectra indicate the square-planar coordination of Cu(II) ion with four O atoms. Copper(II) complex formation with dextran and its derivatives were analyzed by physicochemical methods. Synthesized complexes of Cu(II) ion with reduced low-molar dextran in comparison with commercial preparations showed the considerably lower acute toxicity (LD50 1705).