Journal of Spectroscopy

Journal of Spectroscopy / 2008 / Article

Open Access

Volume 22 |Article ID 942758 |

Leonardo M. Moreira, Landulfo Silveira Jr., Fábio V. Santos, Juliana P. Lyon, Rick Rocha, Renato A. Zângaro, Antonio Balbin Villaverde, Marcos T. T. Pacheco, "Raman spectroscopy: A powerful technique for biochemical analysis and diagnosis", Journal of Spectroscopy, vol. 22, Article ID 942758, 19 pages, 2008.

Raman spectroscopy: A powerful technique for biochemical analysis and diagnosis


The present work focuses on the recent applications of Raman spectroscopy (RS) on biochemical analysis and diagnosis of several biological materials with or without pathological alterations. Important published works about Raman spectroscopy and its use for medical applications were critically reviewed, including articles form our group in order to evaluate the state of the art of the subject. The potential for sample characterization with RS associated to the possibility of analysis in situ makes this instrumental technique in a very auspicious tool of biochemical analysis. RS can promote a significant improvement in the chemical identification and characterization of biological systems, clinical diagnosis and prognosis regarding several diseases and quality of life of innumerous patients. The spectroscopic evaluation is based on the analysis of the Raman spectrum regarding the identification of fingerprint bands of main biological macromolecules, such as nucleic acids, proteins and fat, present in the tissue structure. This review evaluates the employment of RS in diagnosing such pathological manifestations as well as the efforts focused on the instrumental development to biomedical applications. Furthermore, advantages and limitations of this kind of approach are discussed in order to improve the biochemical analysis and diagnosis of several diseases.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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