Journal of Spectroscopy

Journal of Spectroscopy / 2009 / Article

Open Access

Volume 23 |Article ID 769146 | https://doi.org/10.3233/SPE-2009-0378

Changyun Chen, Kai Chen, Qi Long, Meihua Ma, Fei Ding, "Structural characterization and DNA-binding properties of Sm(III) complex with ofloxacin using spectroscopic methods", Journal of Spectroscopy, vol. 23, Article ID 769146, 9 pages, 2009. https://doi.org/10.3233/SPE-2009-0378

Structural characterization and DNA-binding properties of Sm(III) complex with ofloxacin using spectroscopic methods

Abstract

A novel complex Sm(III) complex with ofloxacin was synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, thermal analysis (TG-DSC), 1H-NMR spectra. Then, spectrometric titration, ethdium bromide displacement experiments by UV spectroscopy, ionic influence, viscosity measurements and Circular Dichroism (CD) spectroscopic measurements were conducted to characterize the interaction between the complex and CT-DNA. Results obtained indicate that the complex bound with CT-DNA via an intercalation mechanism. The binding constants and binding sites number of the Sm(III) complex with CT-DNA were 1.80×105 l·mol−1 and 1, respectively.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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