Journal of Spectroscopy

Journal of Spectroscopy / 2010 / Article
Special Issue

From Molecule to Tissue: XIII European Conference on the Spectroscopy of Biological Molecules, Palermo, Italy, August 28–September 2, 2009, Part 2 of 2

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Volume 24 |Article ID 107694 | https://doi.org/10.3233/SPE-2010-0461

S. Garasevych, M. Iakhnenko, O. Slobodyanyuk, I. Vaskivskyi, "Abnormal shifts in Raman spectra of deuterated cytidine and 6-azacytidine", Journal of Spectroscopy, vol. 24, Article ID 107694, 5 pages, 2010. https://doi.org/10.3233/SPE-2010-0461

Abnormal shifts in Raman spectra of deuterated cytidine and 6-azacytidine

Abstract

It was revealed that some peaks in Raman spectra of cytidine, 6-azacytidine (6-azaC), and cytosine dissolved in D2O are shifted to high frequencies in respect to their positions in spectra of H2O solution. Such “blue shifts” occur due to deuteration of the nucleoside molecule itself but not due to effect of deuterated solvent. This conclusion is deduced from observation of blue (abnormal) shift in Raman spectra of cytidine and 6-azaC microcrystals recrystallized from D2O solution. Both normal and abnormal shifts close to the experimentally observed were obtained in the calculated spectra of 6-azaC and cytidine. We assume that abnormal shifts may be caused by substitution of intramolecular H-bonds with D-bonds.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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