Journal of Spectroscopy

Journal of Spectroscopy / 2010 / Article
Special Issue

From Molecule to Tissue: XIII European Conference on the Spectroscopy of Biological Molecules, Palermo, Italy, August 28–September 2, 2009, Part 1 of 2

View this Special Issue

Open Access

Volume 24 |Article ID 317263 | 6 pages |

Multivariate statistical evaluation of bone site and sex as parameters for the Fourier transform infrared spectroscopic study of normal bone


Fourier transform infrared spectroscopy combined with multivariate analysis was performed on a series of bone samples in order to investigate possible differences in the molecular fingerprint based on classification either between different sex and bone sites. Cortical femoral, tibia and ulna samples from five male and five female normal Wistar rats were analysed. PCA analysis classified successfully sex-related spectra since the first three principal components explained 95% of the total variance. This was not the case for bone site-related spectra. In all cases, an important aspect is the ionic exchange of phosphate and carbonate ions.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

377 Views | 366 Downloads | 6 Citations
 PDF  Download Citation  Citation
 Order printed copiesOrder