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Spectroscopy
Volume 25, Issue 1, Pages 1-11
http://dx.doi.org/10.3233/SPE-2010-0486

Algorithm construction methodology for diagnostic classification of near-infrared spectroscopy data

Ramón Guevara,1,2,3 Lynn Stothers,1,2 and Andrew Macnab1,4,5

1Department of Urology, Faculty of Medicine, University of British Columbia, Canada
2UBC Hospital Bladder Care Centre, Vancouver, BC, Canada
3Basque Center on Cognition, Brain and Language, Donostia, Spain
4Stellenbosch Institute for Advanced Study, Wallenberg Research Centre, Stellenbosch University, Stellenbosch, South Africa
5FRCPC, FRCPCH, FCAHS, UBC Hospital Bladder Care Centre, Unit 1B, Room F329, 2211 Wesbrook Mall, BC, Vancouver, V6T 2B5, Canada

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Near-infrared spectroscopy (NIRS) has recognized potential but limited application for non-invasive diagnostic evaluation. Data analysis methodology that reproducibly distinguishes between the presence or absence of physiologic abnormality could broaden clinical application of this optical technique. Methods: Sample data sets from simultaneous NIRS bladder monitoring and invasive urodynamic pressure-flow studies (UDS) are used to illustrate how a diagnostic algorithm is constructed using classification and regression tree (CART) analysis. Misclassification errors of CART and linear discriminant analysis (LDA) are computed and examples of other urological NIRS data likely amenable to CART analysis presented. Results: CART generated a clinically relevant classification algorithm (error 4%) using 46 data sets of changes in chromophore concentration composed of the whole time series without specifying features. LDA did not (error 16%). Using CART NIRS data provided comparable discriminant ability to the UDS diagnostic nomogram for the presence or absence of obstructive pathology (88% specificity, 84% precision). Pilot data examples from children with and without voiding dysfunction and women with mild or severe pelvic floor muscle dysfunction also show potentially diagnostic differences in chromophore concentration. Conclusions: CART analysis can likely be applied in other NIRS monitoring applications intended to classify patients into those with and without pathology.