Quantitative Evaluation of Acetaminophen in Oral Solutions by Dispersive Raman Spectroscopy for Quality Control

Table 1

Set of acetaminophen solutions, respective nominal concentrations, and solvents used in the dilution.

Sample	API nominal concentration (mg/mL)	API nominal concentration (%)	Solvent
J	0	0	Excipient
D	140	70	Excipient
H	160	80	Excipient
C	180	90	Excipient
B	190	95	Excipient
G	200	100	Excipient
PEG	200	100	Polyethylene glycol
A	210	105	Excipient
I	220	110	Excipient
E	240	120	Excipient
F*	260	130	Excipient

∗Solution F was excluded due to problems of acetaminophen solubilization.