Spectrophotometric Determination of Thioridazine Hydrochloride in Tablets and Biological Fluids by Ion-Pair and Oxidation Reactions
Table 1
Optical characteristics and statistical data for the regression equation of the proposed methods.
| | Parameters | Ion-pair | THZ + KMnO4 | | BCG | BCP | IC | MO |
| | λ
max (nm) | 412 | 412 | 610 | 508 | | Beer’s law limit (μg/mL) | 4–28 | 4–32 | 0.4–3.2 | 0.4–2.4 | | Molar absorptivity (L/mol cm) | 1.78 × 103 | 1.58 × 103 | 3.82 × 104 | 5.28 × 104 | | Sandell’s sensitivity (μg/cm2) | 0.2293 | 0.2568 | 0.0106 | 7.71 × 10−3 | | Correlation coefficient () | 0.9988 | 0.9972 | 0.9980 | 0.9993 | | Linear regression equationa | | | | | | 0.01516 | 0.02157 | 0.0105 | 0.0104 | | Slope () | 0.0422 | 0.0392 | 0.24 | 0.2455 | | Intercept () | 0.014 | 0.1087 | 0.4912 | 0.635 | | S.D. of slope () | 1.19 × 10−3 | 1.71 × 10−3 | 8.29 × 10−3 | 8.25 × 10−3 | | S.D. of intercept () | 6.43 × 10−3 | 9.15 × 10−3 | 0.0223 | 0.0222 | | LOD (μg/mL) | — | — | 0.0583 | 0.0641 | | LOQ (μg/mL) | — | — | 0.1943 | 0.2133 |
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aA = a + bC, where A is the absorbance and C is the concentration of THZ in μg/mL.
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