Spectrophotometric Studies on the Thermodynamics of the ds-DNA Interaction with Irinotecan for a Better Understanding of Anticancer Drug-DNA Interactions
Figure 6
Absorption spectra of the competitive interaction between CPT-11 and NR bonded to ds-DNA in the wavelength ranges of (a) 220–600 nm and (b) 400–600 nm. Conditions: = 0.0, 6.7, 13.4, 20.1, 26.8, 33.5, 40.2, 46.9, 53.6, 60.3, and 67.0 μmol L−1 for curves 1–11, = 10.0 μmol L−1, and = 30.5 μmol L−1 in phosphate buffer (0.002 mol L−1, pH 7.5).
