Spectrophotometric Studies on the Thermodynamics of the ds-DNA Interaction with Irinotecan for a Better Understanding of Anticancer Drug-DNA Interactions

Table 1

Some thermodynamic parameters for the CPT-11 binding to ds-DNA at various temperatures.

𝑇(K)	𝐻^∗ (%)	𝐾𝑏 (L mol^−1)	Δ𝐻^o (KJ mol^−1)	Δ𝑆^o (KJ mol^−1 K^−1)
303	10.07	5.77 × 10^3	51.15	241.08
308	10.85	8.77 × 10^3
313	11.82	1.11 × 10^4
318	12.84	1.54 × 10^4

∗Hypochromicity.