The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method

Table 3

Determination of paracetamol, aspirin, and caffeine in Excedrin tablets by the proposed method.

Sample*	Added (mg)			Found (mg)			Recovery (%)
	PAR	ASP	CAF	PAR	ASP	CAF	PAR	ASP	CAF
Brand I	—	—	—	325.78	66.50	331.51	100.24	102.30	102.00
	88.50	65.00	65.13	408.99	128.70	322.70	106.00	95.60	94.00
Brand II	—	—	—	329.48	66.95	328.93	101.37	103.00	101.20
	237.22	195.00	196.57	574.08	273.65	531.40	103.11	106.00	103.00
Average							102.68	101.72	100.05
RSD (%)							2.44	4.31	4.10

^∗Brands 1 and 2 are Excedrin tablets containing paracetamol (325 mg), aspirin (325 mg), and caffeine (65 mg) in each tablet from Bristol-Meys Squibb and Novartis Consumer Health companies for brands 1 and 2, respectively.